Creatine Research Today is a free monthly online journal that collates and summarizes the latest research about Creatine, including details on supplements, side-effects, benefits, dangers, muscle growth.

Treatment monitoring and response prediction with proton MR spectroscopy in AD.

Jessen F, Traeber F, Freymann K, Maier W, Schild HH, Block W

Department of Psychiatry, University of Bonn, Germany. jessen@uni-bonn.de

In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

Published 8 August 2006 in Neurology, 67(3): 528-30.
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