Creatine Research Today is a free monthly online journal that collates and summarizes the latest research about Creatine, including details on supplements, side-effects, benefits, dangers, muscle growth. | ||||||
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Caffeine and creatine use in sport.Tarnopolsky MA Department of Pediatrics and Medicine, McMaster University, Hamilton, Ont., Canada. tarnopol@mcmaster.ca Published 24 February 2011 in Ann Nutr Metab, 57: 1-8. Articles on Creatine published 10 January 2011: Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution. J Hum Evol, 60(2): 205-12. While the hominid fossil record clearly shows that brain size has rapidly expanded over the last ~2.5 M.yr. the forces driving this change remain unclear. One popular hypothesis proposes that metabolic adaptations in response to dietary shifts supported greater encephalization in humans. An increase in meat consumption distinguishes the human diet from that of other great apes. Creatine, an essential metabolite for energy homeostasis in muscle and brain tissue, is abundant in meat and was ... [Abstract] [Full-text] Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution. J Hum Evol, 60(2): 205-12. While the hominid fossil record clearly shows that brain size has rapidly expanded over the last ~2.5 M.yr. the forces driving this change remain unclear. One popular hypothesis proposes that metabolic adaptations in response to dietary shifts supported greater encephalization in humans. An increase in meat consumption distinguishes the human diet from that of other great apes. Creatine, an essential metabolite for energy homeostasis in muscle and brain tissue, is abundant in meat and was ... [Abstract] [Full-text] Articles on Creatine published 4 October 2010: Association among amyloid plaque, lipid, and creatine in hippocampus of TgCRND8 mouse model for Alzheimer disease. J Biol Chem, 285(41): 31202-7. Amyloid peptide (Aβ) aggregation in the brain is a characteristic feature of Alzheimer disease (AD). Previously, we reported the discovery of focally elevated creatine deposits in brain tissue from TgCRND8 mice, which express double mutant (K670N/M671L and V717F) amyloid protein precursor. In this study, frozen hippocampal tissue sections from 5-, 8-, 11-, 14-, and 17-month old TgCRND8 and littermate control mice were examined with Fourier transform infrared microspectroscopy to explore the ... [Abstract] [Full-text] Articles on Creatine published 8 September 2010: Skeletal muscle phosphocreatine recovery after submaximal exercise in children and young and middle-aged adults. J Clin Endocrinol Metab, 95(9): E69-74. CONTEXT: Elderly subjects have reduced mitochondrial function. However, it remains unclear whether the decline in mitochondrial function begins earlier in the life span. OBJECTIVE: The objective of the study was to determine skeletal muscle mitochondrial oxidative phosphorylation by (31)phosphorous-magnetic resonance spectroscopy (MRS) across a variety of age groups. DESIGN: This was a cross-sectional study of 121 healthy normal-weight and overweight individuals from age 8 to 55 yr. SETTING: ... [Abstract] [Full-text] Articles on Creatine published 23 August 2010: Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk. J Nutr, 140(9): 1570-3. During lactation, there may be a higher need for creatine replacement due to the provision of creatine to the milk. Our objectives were to: 1) quantify the creatine concentration in rat milk; 2) determine the origin of milk creatine; 3) determine the activities of the enzymes of creatine synthesis in lactating rats and pups; and 4) quantify the origin of the creatine that accumulates in rat pups. The origin of milk creatine was determined in 4 dams following the administration of (14)C-creatine ... [Abstract] [Full-text] Articles on Creatine published 30 July 2010: Reduced in vivo high-energy phosphates precede adriamycin-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol, 299(2): H332-7. Adriamycin (ADR) is an established, life-saving antineoplastic agent, the use of which is often limited by cardiotoxicity. ADR-induced cardiomyopathy is often accompanied by depressed myocardial high-energy phosphate (HEP) metabolism. Impaired HEP metabolism has been suggested as a potential mechanism of ADR cardiomyopathy, in which case the bioenergetic decline should precede left ventricular (LV) dysfunction. We tested the hypothesis that murine cardiac energetics decrease before LV ... [Abstract] [Full-text] Articles on Creatine published 18 June 2010: Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol, 299(1): F167-77. The metabolic sensor AMP-activated protein kinase (AMPK) regulates several transport proteins, potentially coupling transport activity to cellular stress and energy levels. The creatine transporter (CRT; SLC6A8) mediates creatine uptake into several cell types, including kidney epithelial cells, where it has been proposed that CRT is important for reclamation of filtered creatine, a process critical for total body creatine homeostasis. Creatine and phosphocreatine provide an intracellular, ... [Abstract] [Full-text] Articles on Creatine published 17 June 2010: Creatine for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev, 6: CD005225. BACKGROUND: Creatine, a naturally-occurring nitrogenous organic acid involved in adenosine triphosphate (ATP) production, has been shown to increase survival in mouse models of amyotrophic lateral sclerosis (ALS). Results from human trials, however, have been mixed. Given conflicting results regarding creatine's efficacy, we conducted a systematic review. OBJECTIVES: To systematically examine creatine's efficacy in prolonging ALS survival and in slowing ALS disease progression. SEARCH STRATEGY: ... [Abstract] [Full-text] © 2004-2011 Creatine Research Today. All Rights Reserved. |
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